IFN-κ directs antiviral immunity in human skin
Jafira M. Johnson, Laurellee Payne, Pooja Parameswaran, Yongzhi Chen, Mrinal K. Sarkar, Anthony M. Coon, Joanne Michelle Kahlenberg, Johann Eli Gudjonsson, Katherine A. Fitzgerald, Mehdi Rashighi, Megan H. Orzalli
This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.
bioRxiv · Sep 23, 2026 · PreprintImmunology