Megan H. Orzalli

This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

This study identifies gram-positive bacterial cell wall components, such as peptidoglycan and lipoteichoic acid, as inhibitors of HSV-1 and HSV-2 infection in vitro and in a mouse model.

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.