Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts
Yi-Cheng Tsai, Hiroyuki Uechi, Sean R. Millar, Eileigh Kadijk, Alon Minkovich, John Paul Tsu Ouyang, Karl J. Schreiber, Jie Qi Huang, Carina A. Lyons, Vesal Kasmaeifar, Zhixin Zhang, Rico Barsacchi, Claudia Möbius, Antje Janosch, Jonathan C. Savage, , Ji‐Young Youn
The paper shows that stress granules sequester the CCR4-NOT complex, leading to poly(A) tail lengthening and increased survival transcript abundance under stress.
bioRxiv · Feb 4, 2025 · PreprintCell Biology