Ji‐Young Youn

This study shows that redox surveillance in stress granules prevents TDP-43 aggregation by maintaining a controlled redox environment.

The paper maps the functional landscape of the human intrinsically disordered proteome using evolutionary signatures to classify and predict IDR functions.

This study identifies PRRC2A, PRRC2B, and PRRC2C as stress granule proteins that regulate translation by interacting with the eIF3 complex and 48S PIC factors.

The paper shows that stress granules sequester the CCR4-NOT complex, leading to poly(A) tail lengthening and increased survival transcript abundance under stress.

The paper maps human nuclear bodies using proximity proteomics, identifying new components and regulatory functions in RNA regulation.

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

The paper determines the high-resolution structure of V-ATPase in native synaptic vesicles using cryo-EM, revealing interactions with cholesterol and synaptophysin.

The paper compares noDE and DDA/DIA methods for protein-protein interaction detection, finding noDE provides better sensitivity and identifies more high confident interactors.