Author

Yi-Cheng Tsai

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Anthony A. HymaniD· 2 shared Ji‐Young YouniD· 2 shared Aleksandra V. SergeevaiD· 1 shared Alexander M. MoriniD· 1 shared Alon Minkovich· 1 shared Aman SharmaiD· 1 shared Antje Janosch· 1 shared Carina A. Lyons· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Anthony A. HymanORCID

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Author profile →

3 papers

Recent·Most cited

Redox surveillance of stress granules prevents TDP-43 aggregation

Xiao Yan, Silja Zedlitz, Xuemeng Chen, Yi-Cheng Tsai, Yuefeng Ma, Michael Chen, Linge Li, David Kuster, Jik Nijssen, Aleksandra V. Sergeeva, Yiyang Chen, Casey Welch, Wen Yu, Zongru Li, Marco Messina, , Anthony A. Hyman

This study shows that redox surveillance in stress granules prevents TDP-43 aggregation by maintaining a controlled redox environment.

bioRxiv · Oct 19, 2026 · PreprintCell Biology

Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts

Yi-Cheng Tsai, Hiroyuki Uechi, Sean R. Millar, Eileigh Kadijk, Alon Minkovich, John Paul Tsu Ouyang, Karl J. Schreiber, Jie Qi Huang, Carina A. Lyons, Vesal Kasmaeifar, Zhixin Zhang, Rico Barsacchi, Claudia Möbius, Antje Janosch, Jonathan C. Savage, , Ji‐Young Youn

The paper shows that stress granules sequester the CCR4-NOT complex, leading to poly(A) tail lengthening and increased survival transcript abundance under stress.

bioRxiv · Feb 4, 2025 · PreprintCell Biology

Experiment level curation identifies high confidence transcriptional regulatory interactions in neurodevelopment

Eric Ching-Pan Chu, Alexander M. Morin, Tak Hou Calvin Chang, Tue Gia Nguyen, Yi-Cheng Tsai, Aman Sharma, Chao Chun Liu, Paul Pavlidis

This study curates experimentally verified transcriptional regulatory interactions from literature to build a high-confidence resource for gene regulatory network development.

PLoS Computational Biology · Oct 19, 2021Peer-reviewedGenomics