Anthony A. Hyman

This study shows that redox surveillance in stress granules prevents TDP-43 aggregation by maintaining a controlled redox environment.

This paper designs de novo metalloproteases using RoseTTAFold Diffusion 2, achieving high activity and specificity for cleaving various substrates.

This study shows that biomolecular condensates can sustain pH gradients without energy input by neutralizing charges, revealing their role in creating pH microenvironments.

This study investigates the structural differences in mitotic-centrosome assembly between Drosophila and C. elegans, showing divergent mechanisms involving Cnn and SPD-5 proteins.

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

The paper shows that stress granules sequester the CCR4-NOT complex, leading to poly(A) tail lengthening and increased survival transcript abundance under stress.

This study investigates mesoscale organization of TRIM proteins, finding that TRIM8 truncations cause condensatopathy by disrupting condensation and signaling pathways.

This paper develops a thermodynamic model of non-dilute surface binding and phase separation for membrane-binding proteins and applies it to tight junction formation.

The paper derives a model for molecular transport across phase boundaries in coexisting liquid phases and identifies two physical scenarios that lead to an effective transport resistance.

PICNIC predicts condensate-forming proteins across organisms by analyzing sequence and structure, outperforming existing methods and showing no correlation between disorder content and predicted condensate proteome across species.

The paper shows that actin polymerization counteracts N-WASP prewetting on lipid bilayers, revealing a balance between condensate formation and dissolution in cortical condensates.

The paper characterizes RNA content in individual phase-separated coacervate microdroplets using high-throughput sequencing and identifies sequence motifs associated with RNA accumulation.