GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome
Klaus-Peter Knoch, Antonia Kosok, Zuzana Mariničová, Christiana Lekka, Inna V. Kalaidzidis, Yannis L. Kalaidzidis, Marko Barovic, Antje Petzold, Anke Sönmez, Carolin Wegbrod, Katharina Ganß, Andreas Müller, Alexia Carré, Raphaël Scharfmann, Roberto Mallone, , Michele Solimena
This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.
bioRxiv · Mar 28, 2025 · PreprintCell Biology