Anke Sönmez

pH-dependent trapping of cationic amphiphilic drugs perturbs insulin granule homeostasis

This study shows that cationic amphiphilic drugs (CADs) accumulate in insulin secretory granules via pH-dependent trapping, affecting monoamine storage and pH regulation.

Villin-SNAP25 interaction regulates insulin secretion downstream of ICA512 signaling

This study shows that the Villin-SNAP25 interaction regulates insulin secretion by controlling secretory granule docking sites in response to glucose levels.

GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome

This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.

Post-transcriptional regulation of insulin mRNA storage by G3BP1/2+ condensates in beta cells

The paper shows that G3BP1/2 form condensates with insulin mRNA in beta cells, which dissolve upon glucose stimulation, regulating insulin mRNA storage and translation.

FLIM-based pH measurements reveal incretin-induced rejuvenation of aged insulin secretory granules.

This study uses FLIM to measure pH changes in aged insulin secretory granules and shows that Exendin-4 re-acidifies old granules, suggesting a mechanism for their rejuvenation.