Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition
Wei Yang, Shaobo Cong, Ruoyao Li, Jennifer Schwarz, Thilo Schulze, Raban A Gevelhoff, Xinyan Chen, Sara Ullrich, Kristina Falkenstein, Denis Ott, Pia Eixmann, Angelica Trentino, Antje Thien, Thiérry Heidmann, Ekkehard Schulze, , Wenjing Qi
The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.
Nature Communications · Jul 11, 2025Peer-reviewedCell Biology