Author

Ekkehard Schulze

University of FreiburgORCID 0009-0002-8923-3347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Bettina WarscheidiD· 2 shared Jennifer SchwarziD· 2 shared Ralf BaumeisteriD· 2 shared Wei YangiD· 2 shared Wenjing QiiD· 2 shared Angelica Trentino· 1 shared Antje Thien· 1 shared Denis Ott· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

Bettina WarscheidORCID

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2 papers

Recent·Most cited

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

Wei Yang, Shaobo Cong, Ruoyao Li, Jennifer Schwarz, Thilo Schulze, Raban A Gevelhoff, Xinyan Chen, Sara Ullrich, Kristina Falkenstein, Denis Ott, Pia Eixmann, Angelica Trentino, Antje Thien, Thiérry Heidmann, Ekkehard Schulze, , Wenjing Qi

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

Nature Communications · Jul 11, 2025Peer-reviewedCell Biology

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in C. elegans

Qian Zhao, Erika Donner von Gromoff, Wei Yang, Jennifer Schwarz, Lena Sophie Tittel, Ekkehard Schulze, Bettina Warscheid, Ralf Baumeister, Wenjing Qi

This study identifies HPO-11 as a pseudokinase that inhibits nonsense-mediated decay (NMD) to maintain genome stability in C. elegans by preventing R-loop accumulation and DNA damage.

bioRxiv · Sep 4, 2022 · PreprintMolecular Biology