Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias
Michael W. Rudokas, Margaret McKay, Xiaohong Wu, Jonathan M. Granger, Yancey D. Williams, Markus Bögner, Taekyung Kang, Anton Seyfried, Zeren Toksoy, Marine Cacheux, Lawrence H. Young, Fadi G. Akar
This study shows that AMPK activation by high-fat diet reduces arrhythmia risk by improving cardiac electrophysiology and mitochondrial function.
bioRxiv · Jun 11, 2025 · PreprintPhysiology