Lawrence H. Young

The paper compares the developmental strategies of the enteric nervous system and intrinsic cardiac nervous system to reveal how organ-specific specialization occurs through distinct molecular and cellular mechanisms.

This study identifies HOIL-1 as an atypical E3 ligase that protects the ribosome during nutrient stress, revealing a new signaling pathway involved in cell fate decisions.

The paper identifies PIEZO1 overexpression in HHT2 AVMs and shows that inhibiting PIEZO1 reduces AVM formation in Alk1-deficient mice.

The paper identifies two specialized intrinsic cardiac neuron subtypes in mice that play distinct roles in maintaining cardiac homeostasis and stress resilience.

This study shows that AMPK activation by high-fat diet reduces arrhythmia risk by improving cardiac electrophysiology and mitochondrial function.

This study shows that atrial AMPK deletion shifts metabolism from fatty acid oxidation to pyruvate oxidation and disrupts metabolic pathways, contributing to atrial remodeling and arrhythmia.