Author

Xiaohong Wu

Yale UniversityORCID 0000-0001-5984-3342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:electrophysiology· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Fadi G. AkariD· 3 shared Marine Cacheux· 3 shared Jonathan M. GrangeriD· 2 shared Lawrence H. YoungiD· 2 shared Zeren Toksoy· 2 shared Anton Seyfried· 1 shared Benjamin Strauss· 1 shared Gerald I. ShulmaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPhysiology

Fadi G. AkarORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PhysiologyHeart RhythmPeer-reviewedApr 20, 2026

Myocardial STIM1 deficiency triggers mitochondrial fission to impair electrophysiological function and exacerbate post-MI remodeling

Marine Cacheux, Juan Velasco, Jonathan M. Granger…·Fadi G. Akar

This study shows that reducing STIM1 in cardiomyocytes causes mitochondrial fragmentation and metabolic changes, leading to electrical instability and worsened heart function after a heart attack.

DOI 10.1016/j.hrthm.2026.04.030

mouseelectrophysiology

𝕏 PostBluesky

PhysiologybioRxivPreprintJun 11, 2025

Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias

Michael W. Rudokas, Margaret McKay, Xiaohong Wu…·Fadi G. Akar

This study shows that AMPK activation by high-fat diet reduces arrhythmia risk by improving cardiac electrophysiology and mitochondrial function.

DOI 10.1101/2025.06.11.658631

mouseproteomics

𝕏 PostBluesky

PhysiologybioRxivPreprintAug 29, 2024

Role of AMPK in Atrial Metabolic Homeostasis and Substrate Preference

Zeren Toksoy, Yina Ma, Leigh Goedeke…·Lawrence H. Young

This study shows that atrial AMPK deletion shifts metabolism from fatty acid oxidation to pyruvate oxidation and disrupts metabolic pathways, contributing to atrial remodeling and arrhythmia.

2 citations

mousemetabolomics

𝕏 PostBluesky