Author

Marine Cacheux

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:electrophysiology· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Fadi G. AkariD· 3 shared Xiaohong WuiD· 3 shared Jonathan M. GrangeriD· 2 shared Lawrence H. YoungiD· 2 shared Zeren Toksoy· 2 shared Anton Seyfried· 1 shared Benjamin Strauss· 1 shared Gerald I. ShulmaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersPhysiology

Fadi G. AkarORCID

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3 papers

Recent·Most cited

Myocardial STIM1 deficiency triggers mitochondrial fission to impair electrophysiological function and exacerbate post-MI remodeling

Marine Cacheux, Juan Velasco, Jonathan M. Granger, Xiaohong Wu, Benjamin Strauss, Fadi G. Akar

This study shows that reducing STIM1 in cardiomyocytes causes mitochondrial fragmentation and metabolic changes, leading to electrical instability and worsened heart function after a heart attack.

Heart Rhythm · Apr 20, 2026Peer-reviewedPhysiology

Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias

Michael W. Rudokas, Margaret McKay, Xiaohong Wu, Jonathan M. Granger, Yancey D. Williams, Markus Bögner, Taekyung Kang, Anton Seyfried, Zeren Toksoy, Marine Cacheux, Lawrence H. Young, Fadi G. Akar

This study shows that AMPK activation by high-fat diet reduces arrhythmia risk by improving cardiac electrophysiology and mitochondrial function.

bioRxiv · Jun 11, 2025 · PreprintPhysiology

Role of AMPK in Atrial Metabolic Homeostasis and Substrate Preference

Zeren Toksoy, Yina Ma, Leigh Goedeke, Wenxue Li, Xiaoyue Hu, Xiaohong Wu, Marine Cacheux, Yansheng Liu, Fadi G. Akar, Gerald I. Shulman, Lawrence H. Young

This study shows that atrial AMPK deletion shifts metabolism from fatty acid oxidation to pyruvate oxidation and disrupts metabolic pathways, contributing to atrial remodeling and arrhythmia.

bioRxiv · Aug 29, 2024 · PreprintPhysiology