Inflammasome Profiling in Human Natural Killer Cells under Pro-inflammatory Stimuli and Solid Organ Transplantation
Antonio Astorga-Gamaza, Inés Muela-Zarzuela, Juan Miguel Suárez-Rivero, Alexis Varin, Maarten Naesens, Alessandra Tammaro, Jesper Kers, Juan López-Pérez, Raquel de la Varga-Martínez, Auxiliadora Mazuecos, Baptiste Lamarthée, Mario D. Cordero
This study shows human NK cells can activate inflammasomes in vitro and in transplant patients, with distinct responses in CD56 subsets and sustained activation in renal dysfunction and transplant rejection.
bioRxiv · Apr 17, 2024 · PreprintImmunology