Targeting ALOX5/LTA4H driven granuloma caseation as a host-directed strategy for control of TB associated lung damage
Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Denelle Moodley, Kievershen Nargan, Tamia KJ Lawrence, Kimone L Fisher, Welcome Maepa, Kershnee Thambu, Kapongo D. Lumamba, Pumla Majozi, Antony M. Rapulana, Suraj P. Parihar, Threnesan Naidoo, Rajhmun Madansein, Hlumani Ndlovu, , Mohlopheni Jackson Marakalala
This study shows that targeting ALOX5/LTA4H signaling reduces TB-induced lung damage and improves bactericidal activity through macrophage-driven inflammation.
bioRxiv · Feb 27, 2025 · PreprintImmunology