ImmunologybioRxivPreprint
Targeting ALOX5/LTA4H driven granuloma caseation as a host-directed strategy for control of TB associated lung damage
Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Denelle Moodley…·Mohlopheni Jackson Marakalala
This study shows that targeting ALOX5/LTA4H signaling reduces TB-induced lung damage and improves bactericidal activity through macrophage-driven inflammation.
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