Author

Kievershen Nargan

Africa Health Research InstituteORCID 0000-0002-4247-981XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Adrie J. C. SteyniD· 3 shared Threnesan NaidooiD· 3 shared Kapongo D. LumambaiD· 2 shared Alasdair J. LeslieiD· 1 shared Amy K. BarczakiD· 1 shared Antony M. Rapulana· 1 shared Anupam AgarwaliD· 1 shared Ashendree Govender· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Adrie J. C. SteynORCID

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Author profile →

3 papers

Recent·Most cited

Glucose selectively drives a rapid oxidative burst and immunometabolic reprogramming in human neutrophils during Mycobacterium tuberculosis infection

Krishna C. Chinta, Delon Naicker, Sajid Nadeem, Ritesh Rajesh Sevalkar, Vanessa Pillay, Threnesan Naidoo, Gordon Wells, Kapongo D. Lumamba, Kievershen Nargan, Ashendree Govender, Jeff J Jones, Marion Pang, Baiyi Quan, Tingyu Wang, Michael Lee Roukes, , Adrie J. C. Steyn

bioRxiv · May 7, 2026 · PreprintMicrobiology

A mouse model of TB-associated lung fibrosis reveals persistent inflammatory macrophage populations during treatment

Julie Boucau, Jennie Ruelas Castillo, Threnesan Naidoo, Yuming Liu, Shatavisha Dasgupta, Neha Jain, Nicholas E. Jacobson, Kievershen Nargan, Beth A. Cimini, Kevin W. Eliceiri, Adrie J. C. Steyn, Amy K. Barczak

This study uses a mouse model of TB infection to investigate fibrosis mechanisms, finding persistent inflammatory macrophages and elevated matrix remodeling enzymes during treatment.

The Journal of Infectious Diseases · Jul 7, 2025Peer-reviewedMicrobiology

Targeting ALOX5/LTA4H driven granuloma caseation as a host-directed strategy for control of TB associated lung damage

Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Denelle Moodley, Kievershen Nargan, Tamia KJ Lawrence, Kimone L Fisher, Welcome Maepa, Kershnee Thambu, Kapongo D. Lumamba, Pumla Majozi, Antony M. Rapulana, Suraj P. Parihar, Threnesan Naidoo, Rajhmun Madansein, Hlumani Ndlovu, , Mohlopheni Jackson Marakalala

This study shows that targeting ALOX5/LTA4H signaling reduces TB-induced lung damage and improves bactericidal activity through macrophage-driven inflammation.

bioRxiv · Feb 27, 2025 · PreprintImmunology