Kapongo D. Lumamba

Compositional and interpretable representation of histology using AI foundation models and sparse autoencoders

This paper introduces a human-in-the-loop framework using AI foundation models and sparse autoencoders to interpret H&E histology images and integrate them with molecular spatial profiling.

Glucose selectively drives a rapid oxidative burst and immunometabolic reprogramming in human neutrophils during Mycobacterium tuberculosis infection

Targeting ALOX5/LTA4H driven granuloma caseation as a host-directed strategy for control of TB associated lung damage

This study shows that targeting ALOX5/LTA4H signaling reduces TB-induced lung damage and improves bactericidal activity through macrophage-driven inflammation.