Surface SV2A-Syt1 nanoclusters act as a sequestration hub that limits dynamin-1 recruitment and targeting to recycling synaptic vesicles
Christopher Small, Callista B. Harper, Anmin Jiang, Christiana Kontaxi, Nyakuoy Yak, Anusha Malapaka, Elizabeth C. Davenport, Tristan P. Wallis, Rachel S. Gormal, Merja Joensuu, Ramón Martínez‐Mármol, Michael Alan Cousin, Frédéric A. Meunier
The paper shows that SV2A-Syt1 nanoclusters limit dynamin-1 recruitment, thereby controlling the re-entry of Syt1 into recycling synaptic vesicles.
bioRxiv · Dec 12, 2022 · PreprintNeuroscience