Tristan P. Wallis

Transmitted alpha-synuclein extracellular vesicles downregulate axonal flux of retrograde carriers in recipient neurons

This study shows that transmitted alpha-synuclein extracellular vesicles reduce retrograde axonal transport in recipient neurons, with effects dependent on endogenous alpha-synuclein interaction.

Nanobinders for Synaptotagmin 1 enable the analysis of synapticvesicle dynamics in rodent and human models.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

VAMP2/Munc18-1 domain 3a interaction controls the nanoscale reorganization underpinning vesicular priming

The paper identifies key residues in Munc18-1 domain 3a that regulate the interaction with VAMP2, controlling nanoscale reorganization necessary for vesicular priming and secretion.

Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

DDHD2 interacts with STXBP1 to mediate long-term memory via the generation of myristic acid

This study shows that DDHD2 and STXBP1 interact to generate myristic acid, which is essential for long-term memory formation in mice.

Surface SV2A-Syt1 nanoclusters act as a sequestration hub that limits dynamin-1 recruitment and targeting to recycling synaptic vesicles

The paper shows that SV2A-Syt1 nanoclusters limit dynamin-1 recruitment, thereby controlling the re-entry of Syt1 into recycling synaptic vesicles.

SV2A-Syt1 interaction controls surface nanoclustering and access to recycling synaptic vesicles

This study shows that the SV2A-Syt1 interaction forms surface nanoclusters, which regulate their entry into recycling synaptic vesicles.

Frontotemporal dementia mutant tau (P301L) locks Fyn in an open, active conformation conducive to nanoclustering

This study shows that the tau mutant P301L promotes Fyn nanoclustering by locking it in an open, active conformation, leading to synaptotoxicity.