Frédéric A. Meunier

The paper shows that single-molecule bouncing at a presynaptic interface enables protein enrichment without slowing diffusion.

This study identifies Vaultrc5 as a noncoding RNA that regulates synaptic vault trafficking and RNA cargo dynamics, impacting learning and memory.

This study shows that transmitted alpha-synuclein extracellular vesicles reduce retrograde axonal transport in recipient neurons, with effects dependent on endogenous alpha-synuclein interaction.

The paper investigates NKX2-5 mutations in congenital heart disease by analyzing their epigenomic, biochemical, and chromatin search functions in cardiomyocytes, revealing diverse loss and gain-of-function defects.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

This paper reviews mechanisms of protein kinase nanoclustering and its role in signaling regulation across physiological and pathological contexts.

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

The paper identifies key residues in Munc18-1 domain 3a that regulate the interaction with VAMP2, controlling nanoscale reorganization necessary for vesicular priming and secretion.

The paper identifies actomyosin-II-driven radial contractility as a mechanism protecting central axons from mild mechanical stress and shows its protective role in a traumatic brain injury model.

This study shows that SARS-CoV-2 spike and orthoreovirus p15 proteins induce fusion between neurons and glial cells across species, leading to syncytia and organelle exchange.

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

This study shows that DDHD2 and STXBP1 interact to generate myristic acid, which is essential for long-term memory formation in mice.

This study identifies defective lipid metabolism in Schwann cells as a cause of CMT1A, showing altered lipid composition and membrane dynamics in mouse models and human iPSC-derived cells.

The paper shows that SV2A-Syt1 nanoclusters limit dynamin-1 recruitment, thereby controlling the re-entry of Syt1 into recycling synaptic vesicles.

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.

This study shows that the SV2A-Syt1 interaction forms surface nanoclusters, which regulate their entry into recycling synaptic vesicles.

This study shows that the tau mutant P301L promotes Fyn nanoclustering by locking it in an open, active conformation, leading to synaptotoxicity.

This study identifies hericene A from Hericium erinaceus as a compound with BDNF-like neurotrophic activity that enhances memory in vivo.

This study shows that actomyosin-II radial contractility regulates axonal cargo trafficking and structural stability by controlling transient radial expansion during cargo transport.