Rachel S. Gormal

This study shows that transmitted alpha-synuclein extracellular vesicles reduce retrograde axonal transport in recipient neurons, with effects dependent on endogenous alpha-synuclein interaction.

This paper reviews mechanisms of protein kinase nanoclustering and its role in signaling regulation across physiological and pathological contexts.

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

The paper identifies key residues in Munc18-1 domain 3a that regulate the interaction with VAMP2, controlling nanoscale reorganization necessary for vesicular priming and secretion.

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

This study shows that DDHD2 and STXBP1 interact to generate myristic acid, which is essential for long-term memory formation in mice.

The paper shows that SV2A-Syt1 nanoclusters limit dynamin-1 recruitment, thereby controlling the re-entry of Syt1 into recycling synaptic vesicles.

This study shows that the tau mutant P301L promotes Fyn nanoclustering by locking it in an open, active conformation, leading to synaptotoxicity.

This study identifies hericene A from Hericium erinaceus as a compound with BDNF-like neurotrophic activity that enhances memory in vivo.