Ramón Martínez‐Mármol

This paper reviews mechanisms of protein kinase nanoclustering and its role in signaling regulation across physiological and pathological contexts.

The paper identifies key residues in Munc18-1 domain 3a that regulate the interaction with VAMP2, controlling nanoscale reorganization necessary for vesicular priming and secretion.

This study shows that SARS-CoV-2 spike and orthoreovirus p15 proteins induce fusion between neurons and glial cells across species, leading to syncytia and organelle exchange.

The paper shows that SV2A-Syt1 nanoclusters limit dynamin-1 recruitment, thereby controlling the re-entry of Syt1 into recycling synaptic vesicles.

This study shows that the SV2A-Syt1 interaction forms surface nanoclusters, which regulate their entry into recycling synaptic vesicles.

The paper shows that syntaxin-1 is required for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion in axonal guidance.

This study shows that the tau mutant P301L promotes Fyn nanoclustering by locking it in an open, active conformation, leading to synaptotoxicity.

This study identifies hericene A from Hericium erinaceus as a compound with BDNF-like neurotrophic activity that enhances memory in vivo.