Christopher Small

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

The paper shows that SV2A-Syt1 nanoclusters limit dynamin-1 recruitment, thereby controlling the re-entry of Syt1 into recycling synaptic vesicles.

This study shows that the SV2A-Syt1 interaction forms surface nanoclusters, which regulate their entry into recycling synaptic vesicles.

This study shows that the tau mutant P301L promotes Fyn nanoclustering by locking it in an open, active conformation, leading to synaptotoxicity.