In mouse and in vitro models, bowel preparation promotes pathogen colonization, translocation and exacerbation of inflammation
Charlotte A Clayton, Imogen Porter, Bohan Deng, Giselle McCallum, Apsara Srinivas, Claire Sie, Jerry He, Alexander Pei, Dominique Tertigas, Deanna M. Pepin, Touran Fardeen, Katharine M. Ng, Sidhartha R. Sinha, Michael Gordon Surette, Bruce Andrew Vallance, Carolina Tropini
This study shows that bowel preparation with PEG increases susceptibility to pathogens and exacerbates inflammation in mouse and in vitro models.
Cell Reports Medicine · Dec 22, 2025Peer-reviewedMicrobiology