EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery
H. R. Sagara Wijeratne, Avery M. Runnebohm, Monica P. Barron, Ariana J Hampton, Rudong Li, Sarah A. Peck Justice, Sophia H Lenceski, James D Rooney, Whitney R. Smith-Kinnaman, Gina S Chang, Emma H. Doud, Jungsu Kim, S. William Pelletier, Yunlong Liu, Jonah Z. Vilseck, Amber L. Mosley
The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.
bioRxiv · Jul 13, 2026 · PreprintSystems Biology