Sarah A. Peck Justice

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.

The paper investigates how EXOSC3 S1-domain variants disrupt RNA exosome function, leading to altered rRNA processing and mRNA targeting.

The paper uses proteomics and PISA analysis to study PERK-dependent changes in protein homeostasis during ER stress induced by tunicamycin.

The paper optimizes the analysis workflow for Thermal Proteome Profiling data to improve the accuracy of protein stabilization/destabilization identification and provides an R-based tool for community use.

This paper introduces TeMPP, a method using mass spectrometry to analyze the impact of missense mutations on protein stability and interactions, revealing mechanistic insights not obtainable through transcriptome or proteome analysis alone.

This paper shows that Rtr1 prevents premature transcription termination by restricting the NNS-dependent termination pathway and facilitating low-level elongation of noncoding transcripts.