Antagonistic regulation of HBZ splicing by hnRNPA1 and hnRNPH1 drives HTLV-1 leukemogenesis.
Julie Tram, Célima Mourouvin, Laetitia Marty, Anika Marie-Delcasse, Arnaud Lecante, Raymond Césaire, Philippe Hélias, Stanie Gaëte, Véronique Baccini, Benoı̂t Barbeau, Norbert Donhauser, Andrea K. Thoma‐Kress, Jean-Michel Mesnard, Jean‐Marie Péloponèse
This paper identifies HBZ splicing regulation by hnRNPA1 and hnRNPH1 as a key driver of HTLV-1 leukemogenesis, showing that HBZ_SP1 promotes transformation and chemoresistance in ATL.
bioRxiv · Jul 21, 2026 · PreprintMolecular Biology