Mitochondrial protein import stress augments alpha-synuclein aggregation and neurodegeneration independent of bioenergetics
Liam P. Coyne, Arnav Rana, Xiaowen Wang, Sanaea Z. Bhagwagar, Yumiko Umino, Eduardo C. Solessio, Frank A. Middleton, Xin Jie Chen
This study shows that mitochondrial protein import stress increases alpha-synuclein aggregation and neurodegeneration without affecting bioenergetics in a Parkinson's disease mouse model.
bioRxiv · Sep 20, 2022 · PreprintMolecular Biology