The paper investigates how Cx36 gap junctions in the inner and outer retina affect visual thresholds under dim light using mouse models and behavioral assays, finding distinct roles in threshold control.

iScience · Dec 26, 2025Peer-reviewedNeuroscience

Mitochondrial protein import stress augments alpha-synuclein aggregation and neurodegeneration independent of bioenergetics

Liam P. Coyne, Arnav Rana, Xiaowen Wang, Sanaea Z. Bhagwagar, Yumiko Umino, Eduardo C. Solessio, Frank A. Middleton, Xin Jie Chen

This study shows that mitochondrial protein import stress increases alpha-synuclein aggregation and neurodegeneration without affecting bioenergetics in a Parkinson's disease mouse model.

bioRxiv · Sep 20, 2022 · PreprintMolecular Biology

Cone-driven retinal responses are shaped by rod but not cone HCN1

Colten K. Lankford, Yumiko Umino, Deepak Poria, Vladimir J. Kefalov, Eduardo C. Solessio, Sheila A. Baker

The paper investigates the role of HCN1 channels in retinal signaling, finding that rod-driven responses are affected by HCN1 knockout, while cone-driven responses remain unchanged.

Journal of Neuroscience · Apr 18, 2022Peer-reviewedNeuroscience

Differential impact of Kv8.2 loss on rod and cone signaling and degeneration.

Shivangi M. Inamdar, Colten K. Lankford, Deepak Poria, Joseph G. Laird, Eduardo C. Solessio, Vladimir J. Kefalov, Sheila A. Baker

This study examines the impact of Kv8.2 loss on rod and cone photoreceptor signaling and degeneration using a knockout mouse model.

Human Molecular Genetics · Oct 12, 2021Peer-reviewedNeuroscience