Author

Xin Jie Chen

SUNY Upstate Medical UniversityORCID 0000-0002-8488-6587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Arnav Rana· 2 shared Liam P. CoyneiD· 2 shared Auyon GhoshiD· 1 shared Daniel M. LohiD· 1 shared Eamon Fitzpatrick· 1 shared Eduardo C. SolessioiD· 1 shared Frank A. MiddletoniD· 1 shared Gargi Mishra· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

Arnav Rana

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3 papers

Recent·Most cited

The Mitochondrial F-box protein 1 and DJ-1 homolog HSP31 support cellular proteostasis during mitochondrial protein import clogging

Gargi Mishra, Xiaowen Wang, Eamon Fitzpatrick, Auyon Ghosh, Xin Jie Chen

The paper identifies MFB1 and HSP31 as factors that mitigate mitochondrial protein import defects and cytosolic stress caused by clogging of mitochondrial import complexes.

bioRxiv · Oct 13, 2025 · PreprintGenetics

Mitochondrial protein import stress augments alpha-synuclein aggregation and neurodegeneration independent of bioenergetics

Liam P. Coyne, Arnav Rana, Xiaowen Wang, Sanaea Z. Bhagwagar, Yumiko Umino, Eduardo C. Solessio, Frank A. Middleton, Xin Jie Chen

This study shows that mitochondrial protein import stress increases alpha-synuclein aggregation and neurodegeneration without affecting bioenergetics in a Parkinson's disease mouse model.

bioRxiv · Sep 20, 2022 · PreprintMolecular Biology

Mitochondrial DNA metabolism is coupled with 20S proteasome function via regulation of deoxyribonucleotide homeostasis in Saccharomyces cerevisiae

Xiaowen Wang, Arnav Rana, Liam P. Coyne, Daniel M. Loh, Thuy La, Xin Jie Chen

The paper shows that 20S proteasome function regulates mtDNA stability in yeast by controlling dNTP homeostasis through Sml1 degradation.

bioRxiv · Nov 30, 2021 · PreprintGenetics