Reprogramming Immunosuppressive Bone Marrow Derived Cells via CD44 Targeting Impacts Pancreatic Cancer Metastasis
Lisa-Marie Mehner, Leonel Muñoz‐Sagredo, Geoffroy Andrieux, David Koschut, Matthias M. Gaida, Arne Warth, Philipp Haitz, Sven Máté Treffert, Véronique Orian‐Rousseau
This study shows targeting CD44 on bone marrow-derived cells reduces pancreatic cancer metastasis by disrupting immunosuppressive niches in the liver.
bioRxiv · Aug 13, 2025 · PreprintCancer Biology