Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions
Sven Máté Treffert, Yvonne M. Heneka, Julie Martin, Alessandra Gargano, Larissa Launhardt, Özlem Akilli‐Öztürk, Eliana Stanganello, Geoffroy Andrieux, Dominique Hoch, Steffen Joachim Sonnentag, Lisa-Marie Mehner, Leonel Muñoz‐Sagredo, Michelle Christ, Véronique Orian‐Rousseau
This study shows that CD44 deletion in pancreatic cancer-associated fibroblasts reduces tumor volume, alters their morphology and function, and enhances anti-tumor immune responses.
Cell Death and Disease · Aug 15, 2026Peer-reviewedCancer Biology