Author

David Koschut

Karlsruhe Institute of TechnologyORCID 0000-0003-2204-5165Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Agueda A. RostagnoiD· 1 shared André StrydomiD· 1 shared Anne Rovelet‐LecruxiD· 1 shared Annette Karmiloff‐Smith· 1 shared Aoife MurrayiD· 1 shared Arne Warth· 1 shared Carla Marie StartiniD· 1 shared David Laurence BeckeriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Agueda A. RostagnoORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 13, 2025

Reprogramming Immunosuppressive Bone Marrow Derived Cells via CD44 Targeting Impacts Pancreatic Cancer Metastasis

Lisa-Marie Mehner, Leonel Muñoz‐Sagredo, Geoffroy Andrieux…·Véronique Orian‐Rousseau

This study shows targeting CD44 on bone marrow-derived cells reduces pancreatic cancer metastasis by disrupting immunosuppressive niches in the liver.

DOI 10.1101/2025.08.13.670111

mouseexperimental assay

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NeuroscienceMolecular PsychiatryPeer-reviewedJul 9, 2020

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray…·Henrik Zetterberg

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.

123 citationstop 1%

humanproteomics

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