Cancer BiologyCell Death and DiseasePeer-reviewed
Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions
Sven Máté Treffert, Yvonne M. Heneka, Julie Martin…·Véronique Orian‐Rousseau
This study shows that CD44 deletion in pancreatic cancer-associated fibroblasts reduces tumor volume, alters their morphology and function, and enhances anti-tumor immune responses.