Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus
Zijian Zhang, Jing Xu, Elizabeth A. Matthews, Samantha Deasy, Lewei He, Diego Arroyo, Enhui Pan, Arvin Deshmukh, Kiran Shehnaz Kaur, James O McNamara, Derek G. Southwell, Charles A. Gersbach, Ru-Rong Ji, Dmitry Velmeshev
The paper introduces CRISPR-rabies virus (CRV) to enable precise circuit-level gene modulation in neurons, demonstrating its ability to regulate synaptic transmission in the hippocampus.
bioRxiv · Nov 3, 2025 · PreprintNeuroscience