Dissecting mammalian cortical circuit development at single-cell resolution using inducible barcoded rabies virus
Zijian Zhang, Brooke R. D’Arcy, Lewei He, Diego Arroyo, Samantha Deasy, Elizabeth A. Matthews, Zihan Yan, Nirvika Rastogi, Walter Mancia Leon, Kiran Shehnaz Kaur, Derek G. Southwell, Z. Josh Huang, Debra L. Silver, Dmitry Velmeshev
The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.
bioRxiv · Nov 7, 2025 · PreprintNeuroscience