Author

Zijian Zhang

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Bioinformatics· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Derek G. SouthwelliD· 2 shared Diego Arroyo· 2 shared Dmitry VelmesheviD· 2 shared Elizabeth A. MatthewsiD· 2 shared Kiran Shehnaz Kaur· 2 shared Lewei He· 2 shared Samantha Deasy· 2 shared Arif Harmanci· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Derek G. SouthwellORCID

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4 papers

Recent·Most cited

RDEmbed: A Sentence-Embedding Framework for Rare Disease Phenotype Representation and Phenotypic Similarity Analysis

Xinghua Wang, Jianlian Wang, Zijian Zhang, Hongfang Liu, Arif Harmanci

RDEmbed uses sentence embeddings to analyze rare disease phenotypes from clinical text, outperforming ontology-based methods in similarity analysis and clustering.

bioRxiv · Oct 19, 2026 · PreprintBioinformatics

Gene-Specific Analysis of Clonal Hematopoiesis Identifies ASXL1 as a Risk Factor for Lung Cancer

Zijian Zhang, Jing Dong, Yun Huang, Yanhong Liu, Christopher Ian Amos, Chao Cheng

The paper identifies ASXL1 mutations in clonal hematopoiesis as a risk factor for lung cancer, particularly in smokers, using large population-based cohorts.

bioRxiv · May 26, 2026 · PreprintBioinformatics

Dissecting mammalian cortical circuit development at single-cell resolution using inducible barcoded rabies virus

Zijian Zhang, Brooke R. D’Arcy, Lewei He, Diego Arroyo, Samantha Deasy, Elizabeth A. Matthews, Zihan Yan, Nirvika Rastogi, Walter Mancia Leon, Kiran Shehnaz Kaur, Derek G. Southwell, Z. Josh Huang, Debra L. Silver, Dmitry Velmeshev

The paper develops an inducible barcoded rabies virus to study neuronal circuit development at single-cell and spatial resolution in mice, revealing developmental connectivity patterns and constructing in silico circuit models.

bioRxiv · Nov 7, 2025 · PreprintNeuroscience

Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus

Zijian Zhang, Jing Xu, Elizabeth A. Matthews, Samantha Deasy, Lewei He, Diego Arroyo, Enhui Pan, Arvin Deshmukh, Kiran Shehnaz Kaur, James O McNamara, Derek G. Southwell, Charles A. Gersbach, Ru-Rong Ji, Dmitry Velmeshev

The paper introduces CRISPR-rabies virus (CRV) to enable precise circuit-level gene modulation in neurons, demonstrating its ability to regulate synaptic transmission in the hippocampus.

bioRxiv · Nov 3, 2025 · PreprintNeuroscience