Metabolic-sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum
Alex Reichenbach, Rachel Clarke, Romana Stark, Sarah Haas Lockie, Mathieu Méquinion, Harry Dempsey, Sasha Rawlinson, Felicia M. Reed, Tara Sepehrizadeh, Michael DeVeer, Astrid C Munder, Juan Nunez-Iglesias, David C. Spanswick, Randall L. Mynatt, Alexxai V. Kravitz, , Zane Bruce Andrews
This study shows that impaired metabolic-sensing in AgRP neurons reduces dopamine release in the dorsal striatum and suppresses reward-seeking behavior, especially under hunger.
eLife · Jan 12, 2022Peer-reviewedNeuroscience