Gpr88 deletion impacts motivational control independently of striatal dopamine function
Daisy L. Spark, Michela H. Vermeulen, Patricia Rueda, Rocio De la Fuente Gonzalez, Tara Sepehrizadeh, Michael de Veer, Clotilde Mannoury la Cour, Alex Fornito, Monica Langiu, Gregory D. Stewart, Jess Nithianantharajah, Christopher J. Langmead
This study shows that Gpr88 deletion increases motivational drive in both sexes and impairs cost/benefit decision making in males, without affecting striatal dopamine function.
bioRxiv · May 19, 2022 · PreprintNeuroscience