Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins
Camilla Gustafsen, Joachim Vilstrup, Marianne Kristensen, Ditte Køster, Jonas Lende, Casper Larsen, Amanda Simonsen, Astrid Damgaard Graversen, Ditte Olsen, Lone Tjener Pallesen, Christian Bjerggaard Vægter, Jean‐Claude Kresse, Michael Schou, Kathrin Weyer, Anders Etzerodt, , Simon Glerup
This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.
Cell chemical biology · Mar 27, 2026Peer-reviewedBiochemistry