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Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins

This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.

Meteorin resolves nociceptive hypersensitivity by reducing connexin-mediated coupling in satellite glial cells

This study shows meteorin reduces nociceptive hypersensitivity by decreasing connexin-mediated coupling in satellite glial cells, with long-lasting therapeutic effects in pain models.

Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion

The paper characterizes satellite glial cell (SGC) subtypes in mouse and human dorsal root ganglia using single-cell RNA sequencing and spatial techniques, revealing distinct functional roles and spatial organization.

Hydrogel Electromagnetic Biohybrid Systems Direct Neural Morphogenesis across Central and Peripheral Systems

This paper introduces a hydrogel-electromagnetic biohybrid system that guides neural morphogenesis in both central and peripheral systems, improving neurite extension and functional recovery in human and rat models.

Comparative transcriptional analysis of the satellite glial cell injury response

This study compares the transcriptional response of satellite glial cells to nerve injury using single-cell RNA-seq and identifies a common signature involving cholesterol biosynthesis regulation.