Author

Joachim Vilstrup

Aarhus UniversityORCID 0000-0002-7941-1536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Mathias Kaas OllendorffiD· 2 shared Peder MadseniD· 2 shared Simon GlerupiD· 2 shared Amanda Simonsen· 1 shared Anders Dupont BørglumiD· 1 shared Anders EtzerodtiD· 1 shared Anna Quattropani· 1 shared Astrid Damgaard Graversen· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Mathias Kaas OllendorffORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins

Camilla Gustafsen, Joachim Vilstrup, Marianne Kristensen, Ditte Køster, Jonas Lende, Casper Larsen, Amanda Simonsen, Astrid Damgaard Graversen, Ditte Olsen, Lone Tjener Pallesen, Christian Bjerggaard Vægter, Jean‐Claude Kresse, Michael Schou, Kathrin Weyer, Anders Etzerodt, , Simon Glerup

This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.

Cell chemical biology · Mar 27, 2026Peer-reviewedBiochemistry

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation

Mathias Kaas Ollendorff, Nicolas Chofflet, Deniz Bicer, Sune Skeldal, Jinjie Duan, Benjamin Feller, Joachim Vilstrup, Rosa Groth, Suganya Sivagurunathan, Hesam Dashti, Jan Skov Pedersen, Thomas Mears Werge, Anders Dupont Børglum, Beth A. Cimini, Thouis R. Jones, , Simon Glerup

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

bioRxiv · Feb 16, 2025 · PreprintNeuroscience