BiochemistryCell chemical biologyPeer-reviewed
Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins
Camilla Gustafsen, Joachim Vilstrup, Marianne Kristensen…·Simon Glerup
This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.
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