Cardiac-Detargeted MyoAAV Enables Systemic Nrl-Mediated Fast Myofiber Remodeling and Hypertrophy Across Multiple Skeletal Muscles
Keisuke Hitachi, Shunya Sadaki, Masato Watanabe, Ryosuke Tsuji, Atsushi Kubo, Yuki Yamasaki, Yuri Kiyofuji, Masafumi Inui, Takashi Kudo, Tomohiko Suzuki, Satoru Takahashi, Kunihiro Tsuchida, Ryo Fujita
This paper develops a modified MyoAAV vector that detargets cardiac expression, enabling safe systemic induction of fast myofiber remodeling and hypertrophy in skeletal muscles.
bioRxiv · Apr 23, 2026 · PreprintCell Biology