Author

Ryo Fujita

University of TsukubaORCID 0000-0002-8392-0122Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Shunya Sadaki· 4 shared Ryosuke TsujiiD· 3 shared Takashi KudoiD· 3 shared Edgar JauliaciD· 2 shared Masato WatanabeiD· 2 shared Pascal MaireiD· 2 shared Takuto HayashiiD· 2 shared Adrien Levesque· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCell Biology

Shunya Sadaki

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Continuous Large Maf Activity Maintains Fast Myofiber Identity and Multicellular Homeostasis in Adult Skeletal Muscle

Shunya Sadaki, Ryosuke Tsuji, Tatsuya Matsumoto, Takuto Hayashi, Takehito Sugasawa, Takashi Kudo, Naoki Horii, Kei-ichiro Yasunaga, Edgar Jauliac, Pascal Maire, Yusuke Ono, Satoru Takahashi, Ryo Fujita

bioRxiv · Oct 13, 2026 · PreprintCell Biology

Cardiac-Detargeted MyoAAV Enables Systemic Nrl-Mediated Fast Myofiber Remodeling and Hypertrophy Across Multiple Skeletal Muscles

Keisuke Hitachi, Shunya Sadaki, Masato Watanabe, Ryosuke Tsuji, Atsushi Kubo, Yuki Yamasaki, Yuri Kiyofuji, Masafumi Inui, Takashi Kudo, Tomohiko Suzuki, Satoru Takahashi, Kunihiro Tsuchida, Ryo Fujita

This paper develops a modified MyoAAV vector that detargets cardiac expression, enabling safe systemic induction of fast myofiber remodeling and hypertrophy in skeletal muscles.

bioRxiv · Apr 23, 2026 · PreprintCell Biology

c-MAF transduces fast motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions

Edgar Jauliac, Stéphanie Backer, Shunya Sadaki, Julien Gondin, Aurélie Fessard, Hugues Escoffier, Maeva Roullat, Maxime Di Gallo, Adrien Levesque, Doriane Pereira, Matthieu Dos Santos, Vincent Vuong, Alexander S. Ham, Franck Letourneur, Rémi Pierre, , Pascal Maire

This study identifies c-MAF as a mediator of motoneuron activity in maintaining fast-glycolytic muscle fibers and neuromuscular junctions through chromatin accessibility changes and gene regulation.

bioRxiv · Feb 17, 2026 · PreprintPhysiology

Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle

Shunya Sadaki, Ryosuke Tsuji, Takuto Hayashi, Masato Watanabe, Ryoto Iwai, Gu Wenchao, Ekaterina A. Semenova, Султанов Ринат Илгизович, Желанкин Андрей Викторович, Edward V. Generozov, Ildus I. Ahmetov, Iori Sakakibara, Koichi Ojima, Hidetoshi Sakurai, Masafumi Muratani, , Ryo Fujita

This study identifies large MAF transcription factors as inducers of type IIb myofibers in humans, enhancing glycolytic capacity and correlating with power training.

Skeletal Muscle · Jul 26, 2025Peer-reviewedCell Biology