Satoru Takahashi

Polyvinylpyrrolidone enhances AAV transduction in vitro and shows preliminary utility for subretinal delivery

This study shows that polyvinylpyrrolidone (PVP) enhances AAV transduction in vitro and improves subretinal delivery in vivo.

Continuous Nuclear Export of p62/SQSTM1 Is Essential for Kidney Homeostasis

This study shows that continuous nuclear export of p62 is essential for kidney homeostasis, as its disruption leads to renal failure due to excessive nuclear accumulation and aggregate formation.

Production of cellobiose from ionic liquid-treated cellulose using the highly thermostable cellobiohydrolase HmCel6A-3SNP at 80°C and analysis of enzymatic accessibility to the substrate

This study produces cellobiose from ionic liquid-treated cellulose using a thermostable enzyme at 80°C, achieving higher yields and purity through optimized pretreatment and enzyme conditions.

Cardiac-Detargeted MyoAAV Enables Systemic Nrl-Mediated Fast Myofiber Remodeling and Hypertrophy Across Multiple Skeletal Muscles

This paper develops a modified MyoAAV vector that detargets cardiac expression, enabling safe systemic induction of fast myofiber remodeling and hypertrophy in skeletal muscles.

Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury

This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.

Mafb Deficiency in Myeloid Cells Increases Susceptibility to Mycobacterium tuberculosis Infection in Mice

This study shows that Mafb deficiency in myeloid cells increases susceptibility to Mycobacterium tuberculosis infection in mice by impairing macrophage function and immune cell recruitment.