In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis
Michael Seamus Haney, Archana Shankar, Leonid Olender, Ian Hsu, Masashi Miyauchi, Róbert Pálovics, Grace A. Meaker, Satoshi Kaito, Ola Rizq, Hwei Minn Khoo, Yavor K. Bozhilov, Kyomi J. Igarashi, Joydeep Bhadury, Christy Nicole Munson, Paul K. Mack, , Adam C. Wilkinson
This study uses in vivo CRISPR screening to identify SAGA complex members as key regulators of hematopoiesis, showing their loss impairs blood production and activates interferon pathways.
bioRxiv · Jul 22, 2022 · PreprintGenetics