Author

Hwei Minn Khoo

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam C. WilkinsoniD· 3 shared Yavor K. BozhiloviD· 2 shared Adele Kay FieldingiD· 1 shared Andrew N. HoldingiD· 1 shared Andrew S. MasoniD· 1 shared Andy G.X. ZengiD· 1 shared Aparna D. SinhaiD· 1 shared Archana ShankariD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Adam C. WilkinsonORCID

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Author profile →

3 papers

Recent·Most cited

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

David Kealy, Ruth Ellerington, Suraj Bansal, Jessie J.F. Medeiros, Catherine A. Hawley, Andy G.X. Zeng, Jakub Lukaszonek, Katie A. West, Aparna D. Sinha, Gillian Caalim, Richard T. Gawne, Jacob Pope, B. Rodriguez Lima Ferreira, Nicole-Mae Geli Blacknell, Bryce Drylie, , Katherine S. Bridge

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

Leukemia · Feb 2, 2026Peer-reviewedCancer Biology

Inhibition of MLLT1 limits growth of MLL-AF4 leukaemias without killing healthy haematopoietic stem cells

Shivani Rajhansa, Nicholas T. Crump, Hwei Minn Khoo, Yavor K. Bozhilov, Paul E. Brennan, Oleg Fedorov, Cassandra Adams, Gillian Farnie, Thomas A. Milne, Adam C. Wilkinson

This study shows that inhibiting MLLT1 selectively limits MLL-AF4-driven leukemia growth without harming healthy hematopoietic stem cells.

bioRxiv · Apr 30, 2025 · PreprintCancer Biology

In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis

Michael Seamus Haney, Archana Shankar, Leonid Olender, Ian Hsu, Masashi Miyauchi, Róbert Pálovics, Grace A. Meaker, Satoshi Kaito, Ola Rizq, Hwei Minn Khoo, Yavor K. Bozhilov, Kyomi J. Igarashi, Joydeep Bhadury, Christy Nicole Munson, Paul K. Mack, , Adam C. Wilkinson

This study uses in vivo CRISPR screening to identify SAGA complex members as key regulators of hematopoiesis, showing their loss impairs blood production and activates interferon pathways.

bioRxiv · Jul 22, 2022 · PreprintGenetics